The Shank1 Polyclonal Antibody (PACO18890) is a crucial tool for research involving the Shank1 protein, a key player in synaptic transmission and plasticity. This antibody, derived from rabbits, exhibits high reactivity towards human samples and is specifically validated for use in Western blot applications.Shank1 is a scaffolding protein found at excitatory synapses in the brain, where it plays a crucial role in the organization and function of these synapses. Dysregulation of Shank1 has been linked to various neurological disorders, including autism spectrum disorders and schizophrenia.
Thus, studying the expression and localization of Shank1 using this antibody can provide valuable insights into the pathophysiology of these conditions.By enabling the precise detection and analysis of Shank1 in various cell types, this antibody is an indispensable tool for researchers in neuroscience and neurology. Its ability to specifically bind to Shank1 makes it an ideal choice for investigating the role of Shank1 in synaptic function and dysfunction, paving the way for the development of novel therapeutic strategies targeting neurological disorders.
Antibody Name:
SHANK1 Antibody (PACO18890)
Antibody SKU:
PACO18890
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SHANK1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO18890(SHANK1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
Background:
SHANK1 seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Synonyms:
SH3 and multiple ankyrin repeat domains 1
UniProt Protein Function:
SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19q13.3Cellular Component: postsynaptic membrane; neuron projection; membrane; dendrite; cytoplasm; dendritic spine; plasma membrane; excitatory synapse; ionotropic glutamate receptor complex; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complexMolecular Function: somatostatin receptor binding; protein C-terminus binding; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain bindingBiological Process: negative regulation of actin filament bundle formation; synapse maturation; olfactory behavior; cytoskeletal anchoring; righting reflex; social behavior; habituation; determination of affect; long-term memory; adult behavior; protein complex assembly; neuromuscular process controlling balance; associative learning
