The SLC22A17 Polyclonal Antibody (PACO18896) is a valuable tool for researchers studying SLC22A17, a cell surface transporter protein involved in the transport of organic cations across cell membranes. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. With its ability to bind to the SLC22A17 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in pharmacology, toxicology, and drug development research.SLC22A17 plays a crucial role in the uptake and excretion of numerous endogenous and exogenous substances, including drugs and environmental toxins.
Understanding the function and regulation of SLC22A17 is essential for predicting drug interactions, optimizing drug delivery, and developing targeted therapies for various diseases. The SLC22A17 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of SLC22A17 in health and disease, paving the way for advancements in personalized medicine and precision therapeutics.
Antibody Name:
SLC22A17 Antibody (PACO18896)
Antibody SKU:
PACO18896
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC22A17
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18896(SLC22A17 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Synonyms:
solute carrier family 22, member 17
UniProt Protein Function:
SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
