The SLC24A3 Polyclonal Antibody (PAC020484) is a valuable tool for researchers studying the SLC24A3 protein, which is involved in ion transport and homeostasis in cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the SLC24A3 protein, this antibody enables the detection and analysis of SLC24A3 in various cell types, making it suitable for studies in physiology, pharmacology, and cell biology.
SLC24A3 is a member of the solute carrier family of membrane transport proteins, and its role in ion transport makes it a key player in maintaining cellular balance and function. Dysregulation of SLC24A3 has been linked to various diseases and conditions, highlighting its potential as a therapeutic target. Research into the mechanisms and functions of SLC24A3 is essential for advancing our understanding of cellular physiology and developing interventions for related disorders.
Antibody Name:
SLC24A3 Antibody (PACO20484)
Antibody SKU:
PACO20484
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC24A3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20484(SLC24A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions.
Synonyms:
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
UniProt Protein Function:
SLC24A3: Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium channel activity; calcium ion binding; calcium, potassium:sodium antiporter activity; potassium ion binding; sodium ion bindingBiological Process: cellular calcium ion homeostasis; ion transport
UniProt Protein Details:
NCBI Summary:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
