Description
SLC25A25 Antibody (PACO37066)
The SLC25A25 Antibody (PAC037066) is a polyclonal antibody designed for research involving SLC25A25, a mitochondrial transporter protein involved in cellular energy metabolism. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunofluorescence.SLC25A25 plays a crucial role in transporting metabolites across the mitochondrial membrane, contributing to the maintenance of cellular energy homeostasis. Dysregulation of SLC25A25 has been implicated in various metabolic disorders and diseases including cancer, neurodegenerative diseases, and cardiovascular disorders.
Therefore, studying the function and regulation of SLC25A25 is essential for understanding these pathologies and developing potential therapeutic interventions. The SLC25A25 Antibody (PAC037066) enables precise detection and analysis of SLC25A25 in different cell types, making it a valuable tool for researchers in the fields of biochemistry, cell biology, and metabolic research. Investigating the role of SLC25A25 may lead to novel insights into mitochondrial function and metabolic pathways, with potential implications for the development of targeted therapies for various human diseases.
| Antibody Name: | SLC25A25 Antibody (PACO37066) |
| Antibody SKU: | PACO37066 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Calcium-binding mitochondrial carrier protein SCaMC-2 protein (1-189AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: SLC25A25 antibody at 10µg/ml. Lane 1: Mouse liver tissue. Lane 2: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53, 56, 57, 55, 41 kDa. Observed band size: 53 kDa. |
 | Immunofluorescent analysis of U251 cells using PACO37066 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO37066 at dilution of 1:100. |
| Background: | Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. |
| Synonyms: | Calcium-binding mitochondrial carrier protein SCaMC-2 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Small calcium-binding mitochondrial carrier protein 2) (Solute carrier family 25 member 25), SLC25A25, APC3 KIAA1896 MCSC3 SCAMC2 |
| UniProt Protein Function: | SLC25A25: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Belongs to the mitochondrial carrier family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Mitochondrial; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: mitochondrion; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane Molecular Function:calcium ion binding Biological Process: ATP metabolic process; response to food; response to dietary excess; camera-type eye development; multicellular organism growth; cellular respiration; response to activity |
| NCBI Summary: | The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q6KCM7 |
| NCBI GenInfo Identifier: | 74758042 |
| NCBI Gene ID: | 114789 |
| NCBI Accession: | Q6KCM7.1 |
| UniProt Secondary Accession: | Q6KCM7,Q5SYW7, Q5SYW8, Q5SYX3, Q5VWU2, Q5VWU3, Q5VWU4 Q6KCM4, Q6KCM6, Q6UX48, Q705K2, Q96PZ1, |
| UniProt Related Accession: | Q6KCM7 |
| Molecular Weight: | 469 |
| NCBI Full Name: | Calcium-binding mitochondrial carrier protein SCaMC-2 |
| NCBI Synonym Full Names: | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 |
| NCBI Official Symbol: | SLC25A25Â Â |
| NCBI Official Synonym Symbols: | MCSC; PCSCL; SCAMC-2Â Â |
| NCBI Protein Information: | calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial ATP-Mg/Pi carrier protein 3; short calcium-binding mitochondrial carrier 2; small calcium-binding mitochondrial carrier 2; solute carrier family 25, member 25, isoform a; mitochondrial Ca(2+)-dependent solute carrier protein 3 |
| UniProt Protein Name: | Calcium-binding mitochondrial carrier protein SCaMC-2 |
| UniProt Synonym Protein Names: | Mitochondrial ATP-Mg/Pi carrier protein 3; Mitochondrial Ca(2+)-dependent solute carrier protein 3; Small calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25 |
| Protein Family: | Calcium-binding mitochondrial carrier protein |
| UniProt Gene Name: | SLC25A25Â Â |
| UniProt Entry Name: | SCMC2_HUMAN |
| Antibodies |
| SLC25A25 Antibody (PACO12268) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
