The SLC38A2 Polyclonal Antibody (PACO39354) is a valuable tool for researchers studying SLC38A2, a sodium-coupled neutral amino acid transporter. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the SLC38A2 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in cell biology and metabolism research.
SLC38A2 plays a vital role in the cellular uptake of neutral amino acids, serving as a key component in amino acid transport and metabolism. Its involvement in amino acid homeostasis makes it a promising target for research into metabolic disorders, nutrient uptake, and cancer metabolism. Understanding the function of SLC38A2 is crucial for uncovering new therapeutic approaches for diseases related to amino acid dysregulation and cellular metabolism.
Western blot. All lanes: SLC38A2 antibody at 1.5µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 57, 46 kDa. Observed band size: 57 kDa.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO39354 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO39354 at dilution of 1:100.
Background:
Functions as a sodium-dependent amino acid, transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acid, and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acid, at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Synonyms:
Sodium-coupled neutral amino acid, transporter 2 (Amino acid, transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid, transporter 2) (System A transporter 1) (System N amino acid, transporter 2), SLC38A2, ATA2 KIAA1382 SAT2 SNAT2
UniProt Protein Function:
SLC38A2: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Belongs to the amino acid/polyamine transporter 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integralChromosomal Location of Human Ortholog: 12qCellular Component: axon; brush border; cell soma; dendrite; integral to plasma membrane; plasma membrane; sarcolemmaMolecular Function: amino acid transmembrane transporter activity; protein binding; symporter activityBiological Process: alanine transport; amino acid transport; cellular response to amino acid starvation; cerebral cortex development; female pregnancy; glutamate secretion; glycine betaine transport; ion transport; neurotransmitter secretion; sodium ion transport; synaptic transmission; transmembrane transport
Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2
