The SLC39A1 Antibody (PAC033876) is a valuable tool for researchers studying SLC39A1, a crucial protein involved in cellular zinc transport and homeostasis. This polyclonal antibody, produced in rabbits, is specifically designed for detecting SLC39A1 in human samples and has been validated for use in Western blot applications. By binding to the SLC39A1 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in molecular biology and physiology.SLC39A1, also known as ZIP1, plays a pivotal role in maintaining zinc balance within cells and is involved in a variety of physiological processes, including immune function, growth, and development.
Dysregulation of SLC39A1 has been linked to various diseases, such as cancer, diabetes, and neurodegenerative disorders, highlighting its importance as a potential therapeutic target. Understanding the function of SLC39A1 is essential for unraveling the mechanisms underlying these conditions and developing novel treatments to address them effectively.
Antibody Name:
SLC39A1 Antibody (PACO33876)
Antibody SKU:
PACO33876
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc transporter ZIP1 protein (126-179AA)
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.
Synonyms:
Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1), SLC39A1, IRT1 ZIP1 ZIRTL
UniProt Protein Function:
SLC39A1: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. Belongs to the ZIP transporter (TC 2.A.5) family.Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q21Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane; plasma membraneMolecular Function: inorganic cation transmembrane transporter activity; zinc ion transmembrane transporter activity; receptor bindingBiological Process: transmembrane transport; cation transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
