The SLC41A2 Polyclonal Antibody (PACO20509) is a valuable tool for researchers studying SLC41A2, a transmembrane protein responsible for regulating magnesium transport within cells. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SLC41A2 protein, this antibody allows for the detection and analysis of magnesium transport mechanisms in various cell types, making it ideal for studies in physiology and disease pathology.SLC41A2 plays a crucial role in maintaining cellular magnesium homeostasis, a process essential for numerous biological functions including enzyme activity, muscle contraction, and nerve function.
Dysregulation of magnesium levels has been linked to conditions such as cardiovascular disease, diabetes, and neurodegenerative disorders, making SLC41A2 a promising target for therapeutic interventions. By furthering our understanding of SLC41A2 function, researchers can uncover new insights into the role of magnesium in health and disease, ultimately leading to the development of novel treatment strategies.
Antibody Name:
SLC41A2 Antibody (PACO20509)
Antibody SKU:
PACO20509
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC41A2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20509(SLC41A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20509(SLC41A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC41A2 (solute carrier family 41, member 2), also known as SLC41A1-L, is a 573 amino acid, multi-pass membrane protein that belongs to the SLC41A transporter family that includes SLC41A1 and SLC41A3. Expressed in lymphocytes and localizing to the cell membrane, SLC41A2 contains twelve transmembrane domains, three myristoylation sequences, numerous possible phosphorylation sites and a putative N-glycosylation site. SLC41A2 is believed to function as a plasma-membrane magnesium transporter. Magnesium, a cofactor for ATP, plays a vital role in metabolic and biochemical processes.
Synonyms:
solute carrier family 41 (magnesium transporter), member 2
UniProt Protein Function:
SLC41A2: Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family.Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Channel, cation; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12q23.3Cellular Component: plasma membraneMolecular Function: magnesium ion transmembrane transporter activity; protein bindingBiological Process: transmembrane transport
