The SLC43A2 Polyclonal Antibody (PAC020512) is a valuable tool for researchers studying the SLC43A2 protein, a key player in amino acid transport and metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the SLC43A2 protein, researchers can analyze and detect its expression in various cell types, making it an ideal choice for studies in biochemistry, molecular biology, and metabolic disorders.SLC43A2, also known as the solute carrier family 43 member 2, is responsible for the transport of neutral amino acids across cell membranes. This function is crucial in maintaining cellular homeostasis and regulating metabolic processes.
Research into SLC43A2 is essential for understanding its role in amino acid uptake and utilization, with implications for diseases related to amino acid metabolism imbalances, including metabolic disorders and cancer.The SLC43A2 Polyclonal Antibody is a valuable tool for investigating the function and regulation of SLC43A2 in various biological contexts. Its high specificity and reactivity make it an excellent choice for researchers seeking to unravel the complexities of amino acid transport and metabolism, with potential implications for therapeutic interventions targeting metabolic pathways.
Antibody Name:
SLC43A2 Antibody (PACO20512)
Antibody SKU:
PACO20512
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SLC43A2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20512(SLC43A2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
Background:
SLC43A2 (solute carrier family 43, member 2), also known as LAT4 or PP7664, is a 569 amino acid, multi-pass membrane protein that belongs to the SLC43A solute transporter family. Expressed in a variety of tissues with highest expression in kidney and placenta, SLC43A2 functions as a sodium- and chloride-independent transport channel protein that facilitates the transport of large neutral amino acid, across membranes. Overexpression of SLC43A2 is associated with head and neck carcinomas, implicating SLC43A2 as a tumor-associated protein.
Synonyms:
solute carrier family 43 (amino acid, system L transporter), member 2
UniProt Protein Function:
SLC43A2: Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. Belongs to the SLC43A transporter (TC 2.A.1.44) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC familyChromosomal Location of Human Ortholog: 17p13.3Cellular Component: plasma membrane; integral to membraneMolecular Function: L-amino acid transmembrane transporter activityBiological Process: amino acid transport; ion transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]
