The SLC43A2 Polyclonal Antibody (PAC020513) is a valuable tool for researchers studying SLC43A2, a solute carrier protein involved in amino acid transport. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SLC43A2 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for studies in metabolism, nutrition, and cellular uptake mechanisms.
SLC43A2 is a key player in amino acid homeostasis, playing a crucial role in nutrient sensing and cellular growth regulation. Its involvement in amino acid transport makes it essential for understanding metabolic pathways and for developing targeted therapies for conditions related to nutrient metabolism, such as metabolic disorders and cancer. Research on SLC43A2 with the use of this antibody can potentially lead to insights into novel treatment strategies for these diseases.
Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane: Human normal stomach tissue,Primary antibody: PACO20513(SLC43A2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20513(SLC43A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC43A2 (solute carrier family 43, member 2), also known as LAT4 or PP7664, is a 569 amino acid, multi-pass membrane protein that belongs to the SLC43A solute transporter family. Expressed in a variety of tissues with highest expression in kidney and placenta, SLC43A2 functions as a sodium- and chloride-independent transport channel protein that facilitates the transport of large neutral amino acid, across membranes. Overexpression of SLC43A2 is associated with head and neck carcinomas, implicating SLC43A2 as a tumor-associated protein.
Synonyms:
solute carrier family 43 (amino acid, system L transporter), member 2
UniProt Protein Function:
SLC43A2: Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. Belongs to the SLC43A transporter (TC 2.A.1.44) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC familyChromosomal Location of Human Ortholog: 17p13.3Cellular Component: plasma membrane; integral to membraneMolecular Function: L-amino acid transmembrane transporter activityBiological Process: amino acid transport; ion transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]
