The SLC45A3 Polyclonal Antibody (PACO56046) is a valuable tool for researchers studying the SLC45A3 protein, which plays a key role in melanin synthesis and skin pigmentation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blotting applications. By targeting the SLC45A3 protein, researchers can accurately detect and analyze its expression in various cell types, providing important insights into melanin production and its implications for skin health and pigmentation disorders.
SLC45A3, also known as solute carrier family 45 member 3, is essential for the transport of tyrosine, a precursor of melanin, in melanocytes. Mutations in the SLC45A3 gene have been associated with pigmentation disorders such as oculocutaneous albinism, highlighting its crucial role in melanin biosynthesis. By studying the function of SLC45A3, researchers can further understand the mechanisms underlying skin pigmentation and potentially develop new therapeutic strategies for pigmentation-related conditions.
IHC image of PACO56046 diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with PACO56046 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO56046 diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
plasma membrane, sucrose:proton symporter activity, sugar transmembrane transporter activity, glucose transport, positive regulation of fatty acid, biosynthetic process, positive regulation of glucose metabolic process, regulation of oligodendrocyte differentiation, sucrose transport
Synonyms:
Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein), SLC45A3, PCANAP6 PRST
UniProt Protein Function:
SLC45A3: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.Protein type: Cell surface; Enzyme, misc.; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q32.1Molecular Function: sucrose:hydrogen symporter activityBiological Process: positive regulation of fatty acid biosynthetic process; regulation of oligodendrocyte differentiation; sucrose transport
