The SLC8B1 Antibody (PACO05390) is a highly specific antibody designed for research involving the SLC8B1 protein, which is a member of the Na+/Ca2+ exchanger family. This antibody is raised in rabbits and is optimized for use in Western blot applications. It has been validated for use with human samples, enabling accurate detection and analysis of the SLC8B1 protein in various cell types.SLC8B1 plays a crucial role in ion homeostasis and calcium signaling, making it a key player in cellular physiology and function. Its involvement in calcium regulation also suggests potential implications in diseases related to calcium dysregulation, such as cardiovascular disorders and neurological diseases.
By utilizing the SLC8B1 Antibody, researchers can gain insights into the function and regulation of SLC8B1 in different cellular contexts, helping to advance our understanding of calcium signaling pathways and their role in health and disease. This antibody is a valuable tool for studies in molecular biology, pharmacology, and neuroscience, providing a deeper understanding of cellular processes and potential therapeutic targets.
Antibody Name:
SLC8B1 Antibody (PACO05390)
Antibody SKU:
PACO05390
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human NCKX6.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC24A6; NCKX6; NCLX; Sodium/potassium/calcium exchanger 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; Solute carrier family 24 member 6
UniProt Protein Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
UniProt Protein Details:
NCBI Summary:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
