The SLC8B1 Antibody (PAC020487) is a polyclonal antibody specifically designed for research involving SLC8B1, a sodium/calcium exchanger protein involved in ion transport and cellular signaling. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.SLC8B1 plays a crucial role in regulating intracellular calcium levels, which is essential for various cellular processes including muscle contraction, neuronal signaling, and cell growth. Dysregulation of SLC8B1 has been implicated in diseases such as heart failure, neurodegenerative disorders, and cancer, making it a potential therapeutic target for drug development.
The SLC8B1 Antibody enables the detection and analysis of SLC8B1 protein in different cell types and tissues, making it an invaluable tool for studying the function and regulation of SLC8B1 in various physiological and pathological conditions. Researchers studying ion transport, cellular signaling, and disease mechanisms will find this antibody essential for their experiments.
Antibody Name:
SLC8B1 Antibody (PACO20487)
Antibody SKU:
PACO20487
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC24A6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO20487(SLC24A6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20487(SLC24A6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).
Synonyms:
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
UniProt Protein Function:
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
UniProt Protein Details:
NCBI Summary:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]
