The SLC9A7 Polyclonal Antibody (PAC018907) is a research tool specifically designed for studying SLC9A7, a member of the solute carrier family that plays a role in ion exchange and cellular homeostasis. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications.SLC9A7, also known as sodium/hydrogen exchanger 7, is involved in the regulation of intracellular pH and plays a key role in cell growth and survival. Dysregulation of SLC9A7 has been linked to various diseases, including cancer and neurological disorders.
By targeting SLC9A7 with this antibody, researchers can investigate its function and potentially uncover new insights into disease mechanisms.With its ability to detect and analyze SLC9A7 in different cell types, this antibody is well-suited for studies in cell biology, physiology, and disease pathology. By understanding the role of SLC9A7 in cellular processes, researchers can pave the way for the development of targeted therapies and diagnostic tools for a range of health conditions.
Antibody Name:
SLC9A7 Antibody (PACO18907)
Antibody SKU:
PACO18907
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SLC9A7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18907(SLC9A7 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants.
Synonyms:
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
UniProt Protein Function:
SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 16p13.3Cellular Component: cytoplasm; nucleusMolecular Function: DNA binding; protein heterodimerization activity; transcription factor bindingBiological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis
UniProt Protein Details:
NCBI Summary:
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
