The SMAGP Polyclonal Antibody (PAC020548) is a valuable tool for researchers studying SMAGP, a key protein involved in the regulation of immune responses. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SMAGP protein, this antibody allows for the detection and analysis of SMAGP in various cell types, making it an ideal choice for studies in immunology and cancer research.SMAGP, also known as immune modulatory protein, plays a crucial role in modulating immune responses and maintaining immune balance. Its involvement in immune regulation highlights its importance in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function of SMAGP is essential for the development of therapies aimed at manipulating immune responses in these disease contexts.Overall, the SMAGP Polyclonal Antibody is a reliable tool for researchers looking to delve into the mechanisms of immune regulation and its implications in various disease states. Its specificity and sensitivity make it a valuable asset in the exploration of SMAGP-related pathways and potential therapeutic targets.
Antibody Name:
SMAGP Antibody (PACO20548)
Antibody SKU:
PACO20548
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SMAGP
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20548(SMAGP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20548(SMAGP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SMAGP (small transmembrane and glycosylated protein) is a 97 amino acid, single-pass type III membrane protein that localizes to the membrane of cytoplasmic vesicles. Existing as a murine-specific protein, SMAGP is thought to play a role in epithelial cell-cell contacts and, via its ability to control cell adhesion, may be involved in tumor formation, as well as overall tumor invasiveness and metastasis. SMAGP is subject to post-translational O-glycosylation which is thought to be modified with sialic acid, residues. The gene encoding SMAGP maps to murine chromosome 15.
Synonyms:
small cell adhesion glycoprotein
UniProt Protein Function:
SMAGP: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation. Belongs to the SMAGP family.Protein type: Vesicle; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13.13Cellular Component: nucleoplasm; cytoplasmic vesicle membrane; plasma membrane; integral to membrane; cell junction
