The SMOC2 Polyclonal Antibody (PAC020559) is a valuable tool for researchers studying SMOC2, a secreted extracellular matrix protein involved in various cellular processes such as cell adhesion, migration, and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the SMOC2 protein, researchers can accurately detect and analyze its expression in different cell types, making it a versatile tool for studies in developmental biology, cancer research, and tissue regeneration.
SMOC2 is known for its role in regulating cell behavior and tissue development, making it a promising target for investigating diseases related to abnormal cell growth and tissue formation. Its functions in promoting cell adhesion and migration suggest potential implications in cancer metastasis and wound healing processes. Understanding the mechanisms by which SMOC2 influences cellular activities is essential for developing targeted therapies and interventions in various disease conditions involving tissue remodeling and regeneration.
Antibody Name:
SMOC2 Antibody (PACO20559)
Antibody SKU:
PACO20559
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SMOC2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20559(SMOC2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the SPARC family (secreted protein acid, c and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains.
Synonyms:
SPARC related modular calcium binding 2
UniProt Protein Function:
SMOC2: Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1). A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Calcium-binding; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 6q27Disease: Dentin Dysplasia, Type I
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
