The SMOC2 Antibody (PAC020560) is a valuable tool for researchers studying SMOC2, a protein involved in various biological processes such as cell adhesion, migration, and tissue development. This polyclonal antibody, produced in rabbits, exhibits high reactivity towards human samples and is specifically validated for use in Western blot applications.SMOC2, also known as SPARC-related modular calcium-binding protein 2, plays a critical role in extracellular matrix organization and signaling pathways. Its versatile functions make it a promising target for research in developmental biology, cancer, and tissue regeneration.
By detecting and analyzing SMOC2 protein expression in different cell types, this antibody enables researchers to explore the role of SMOC2 in various physiological and pathological contexts.Understanding the molecular mechanisms underlying SMOC2's functions can lead to novel insights into disease progression and therapeutic strategies. With its high specificity and reliability, the SMOC2 Antibody is an essential tool for advancing research in diverse fields such as cell biology, oncology, and regenerative medicine.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20560(SMOC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human placenta tissue, Primary antibody: PACO20560(SMOC2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20560(SMOC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the SPARC family (secreted protein acid, c and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains.
Synonyms:
SPARC related modular calcium binding 2
UniProt Protein Function:
SMOC2: Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1). A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Calcium-binding; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 6q27Disease: Dentin Dysplasia, Type I
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
