The SNX11 Antibody (PACO17135) is an essential tool for researchers studying SNX11, a sorting nexin protein involved in endosomal sorting and cellular trafficking processes. This polyclonal antibody, produced via immunization of rabbits, exhibits high specificity and reactivity towards SNX11 in human samples, making it a reliable choice for Western blot applications.SNX11 is a key player in intracellular membrane trafficking pathways, contributing to the proper sorting of proteins and lipids in the endosomal system.
Dysregulation of SNX11 has been linked to various diseases, including neurodegenerative disorders and cancer, emphasizing the importance of studying its functions. By using the SNX11 Antibody, researchers can accurately detect and analyze SNX11 expression in different cell types, aiding in the exploration of its role in cellular processes and disease pathogenesis.
Antibody Name:
SNX11 Antibody (PACO17135)
Antibody SKU:
PACO17135
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SNX11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17135(SNX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17135(SNX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein.
Synonyms:
sorting nexin 11
UniProt Protein Function:
SNX11: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 17q21.32Cellular Component: endosome; extrinsic to membraneMolecular Function: protein bindingBiological Process: endocytosis; vesicle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]
