The SNX11 Polyclonal Antibody (PAC017136) from AssayGenie is a valuable tool for researchers studying SNX11, a member of the sorting nexin family of proteins involved in intracellular trafficking and protein sorting. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in a variety of applications, including Western blotting.SNX11 plays a critical role in endosomal sorting and recycling pathways, contributing to cellular homeostasis and signaling. Dysfunction of SNX11 has been implicated in various diseases, including neurodegenerative disorders and cancer.
By targeting SNX11 with this antibody, researchers can investigate its role in cellular processes and disease pathogenesis, potentially leading to the development of novel therapeutic strategies.Overall, the SNX11 Polyclonal Antibody (PAC017136) is a valuable tool for researchers interested in studying SNX11 and its implications in health and disease. Its high reactivity and specificity make it a reliable choice for experiments in molecular and cellular biology, offering insights into the functions of this important protein.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17136(SNX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: PACO17136(SNX11 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17136(SNX11 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein.
Synonyms:
sorting nexin 11
UniProt Protein Function:
SNX11: May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 17q21.32Cellular Component: endosome; extrinsic to membraneMolecular Function: protein bindingBiological Process: endocytosis; vesicle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]
