The SNX20 Polyclonal Antibody (PAC017141) is a valuable tool for researchers studying SNX20, a protein involved in intracellular trafficking and endosomal sorting. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SNX20 protein, this antibody allows for the detection and analysis of SNX20 in various cell types, making it ideal for studies in cell biology and neuroscience research.SNX20 is a member of the sorting nexin family, which plays a crucial role in regulating the trafficking of proteins within cells.
Its involvement in endosomal sorting processes makes it a key player in cellular homeostasis and signal transduction. By targeting SNX20, researchers can gain insights into the mechanisms underlying intracellular trafficking and its implications in various cellular processes.The SNX20 Polyclonal Antibody is a valuable tool for researchers seeking to elucidate the functions of SNX20 and its role in cellular physiology. With its high reactivity and specificity, this antibody enables the accurate detection and analysis of SNX20, facilitating further exploration of its functions in health and disease.
Antibody Name:
SNX20 Antibody (PACO17141)
Antibody SKU:
PACO17141
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human SNX20
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17141(SNX20 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17141(SNX20 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.
Synonyms:
sorting nexin 20
UniProt Protein Function:
SNX20: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocytes recruitment. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 16q12.1Cellular Component: plasma membrane; endosome membrane; nucleusMolecular Function: protein binding; phosphoinositide bindingBiological Process: protein transport
UniProt Protein Details:
NCBI Summary:
SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010]
