The SNX29 Polyclonal Antibody (PAC020573) is a valuable tool for researchers studying SNX29, a protein involved in endocytosis and intracellular trafficking processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SNX29 protein, this antibody allows for the detection and analysis of SNX29 in various cell types, making it an essential component of studies focusing on cellular trafficking mechanisms and protein turnover.SNX29 is known to play a crucial role in the sorting and recycling of membrane proteins within cells, influencing various cellular processes such as signaling, metabolism, and cell growth.
Dysregulation of SNX29 function has been linked to diseases like cancer, neurodegenerative disorders, and metabolic syndromes, underscoring the importance of studying its molecular activity. By elucidating the functions of SNX29, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic targets for intervention.
Antibody Name:
SNX29 Antibody (PACO20573)
Antibody SKU:
PACO20573
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SNX29
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20573(SNX29 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20573(SNX29 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SNX29 also known as RUNDC2A, is a 375 amino protein that contains one RUN domain. RUNDC2A is encoded by a gene that maps to human chromosome 16p13.13, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Synonyms:
sorting nexin 29
UniProt Protein Function:
SNX29: Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: VesicleChromosomal Location of Human Ortholog: 16p13.13-p13.12
