The SNX8 Antibody (PACO17138) is a high-quality polyclonal antibody designed for research involving sorting nexin 8, a protein involved in endosomal sorting and trafficking pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting and immunofluorescence.SNX8 plays a crucial role in the regulation of endosomal sorting and trafficking, influencing processes such as receptor recycling and degradation. Its involvement in cellular pathways related to protein trafficking and signaling makes it a valuable target for research in cell biology and molecular biology.
The SNX8 Antibody enables the specific detection and analysis of SNX8 protein levels in different cell types, providing valuable insights into its function and potential implications for diseases related to aberrant endosomal sorting. Researchers studying intracellular trafficking mechanisms or seeking to understand the role of SNX8 in various cellular processes will find this antibody to be a valuable tool in their investigations.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17138(SNX8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 cells, hela cells, Primary antibody: PACO17138(SNX8 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17138(SNX8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX8 is an ortholog of a yeast protein.
Synonyms:
sorting nexin 8
UniProt Protein Function:
SNX8: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Belongs to the sorting nexin family.Chromosomal Location of Human Ortholog: 7p22.3Cellular Component: early endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; retromer complexMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: endocytosis; intracellular protein transport; vesicle organization and biogenesis
