The SORL1 Antibody (CAB13047) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbit hosts, demonstrates high specificity and sensitivity for SorLA in human samples, making it ideal for Western blot applications.SorLA, a member of the VPS10P domain receptor family, has been implicated in Alzheimer's disease, cardiovascular disorders, and lipid metabolism.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
SORL1 Antibody
SKU:
CAB13047
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Endosome, Golgi Apparatus, Membrane, Secreted, Single-Pass Type I Membrane Protein.
Calculated MW:
248kDa
Observed MW:
260kDa
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease.
Purification Method
Affinity purification
Gene ID
6653
RRID
AB_2759895
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using SORL1 Rabbit pAb (CAB13047) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
