The SPATA13 Antibody (PAC015057) is a polyclonal antibody designed for research involving SPATA13, a protein associated with spermatogenesis and fertility. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.SPATA13 is a vital protein involved in the process of sperm production and has been linked to male infertility. Research on SPATA13 aims to understand its role in spermatogenesis and fertility, as well as its potential implications in reproductive health and disorders related to infertility.
This SPATA13 Antibody is an essential tool for researchers studying reproductive biology, infertility, and related fields. Its specificity and reliability make it ideal for detecting and analyzing SPATA13 expression in various cell types, providing valuable insights into the mechanisms underlying fertility and reproductive disorders.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15057(SPATA13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO15057(SPATA13 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15057(SPATA13 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.
