The SPATA20 Polyclonal Antibody (PACO18921) is a valuable tool for researchers studying SPATA20, a protein involved in spermatogenesis and fertility. This antibody, generated in rabbits, is specifically tailored for use in Western blot applications and is highly reactive with human samples. By binding to the SPATA20 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for studies in reproductive biology and infertility research.SPATA20, also known as Spermatogenesis-Associated Protein 20, is essential for the proper development of sperm cells and plays a crucial role in male fertility.
Research on SPATA20 can provide insights into the mechanisms underlying male infertility and may lead to the development of new diagnostic tools and therapeutic interventions for individuals struggling with fertility issues. By studying the function of SPATA20, researchers can deepen their understanding of the molecular processes involved in spermatogenesis and potentially uncover novel targets for fertility treatments.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18921(SPATA20 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane 1-3: A549 cells, lncap cells, human seminoma tissue, Primary antibody: PACO18921(SPATA20 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18921(SPATA20 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein may play a role in fertility regulation. It were significantly upregulated in individual bile samples from Cholangiocarcinoma patients by Western blotting and Immunohistochemistry, relative to normal tissues.It acts as a potential serum diagnostic biomarker for Cholangiocarcinoma.
Synonyms:
spermatogenesis associated 20
UniProt Protein Function:
SPATA20: May play a role in fertility regulation. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 17q21.33Cellular Component: extracellular regionMolecular Function: catalytic activityBiological Process: metabolic process; multicellular organismal development; spermatogenesis; cell differentiation
