The SPATA5L1 Polyclonal Antibody (PAC020593) offered by Assaygenie is a valuable tool for researchers studying SPATA5L1, a protein involved in various cellular processes such as DNA repair and apoptosis. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SPATA5L1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.SPATA5L1 is a critical player in the maintenance of genome stability and cellular homeostasis, making it a target of interest in cancer research and other disease studies.
Understanding the role of SPATA5L1 in DNA repair mechanisms and cell survival is essential for developing targeted therapies for cancer and other genetic disorders. With the SPATA5L1 Polyclonal Antibody from Assaygenie, researchers can confidently investigate the function and regulation of SPATA5L1 in their experiments, paving the way for advancements in biomedical research.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20593(SPATA5L1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-2: A549 cells, A172 cells, Primary antibody: PACO20593(SPATA5L1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20593(SPATA5L1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SPATA5L1 (spermatogenesis-associated protein 5-like protein 1) is a 753 amino acid, protein belonging to the AAA ATPase family and AFG2 subfamily. Single nucleotide polymorphisms (SNPs) present in SPATA5L1 at the glycine amidinotransferase (GATM)-SPATA5L1 locus have been found to correlate with glomerular filtration rate (GFR), having significant implications for kidney disease research. SPATA5L1 localizes to cytoplasm and exists as three alternatively spliced isoforms.
Synonyms:
spermatogenesis associated 5-like 1
UniProt Protein Function:
SPATA5L1: Belongs to the AAA ATPase family. AFG2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 15q21.1Cellular Component: cytoplasmMolecular Function: ATP binding
