The SRCIN1 Polyclonal Antibody (PAC06718) is a valuable tool for researchers studying SRCIN1, a protein involved in various cellular processes, including DNA repair and regulation of gene expression. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SRCIN1 protein, this antibody allows for the detection and analysis of SRCIN1 levels in different cell types, making it ideal for studies in cancer research and molecular biology.
SRCIN1, also known as SRC kinase signaling inhibitor 1, plays a crucial role in controlling cell growth and proliferation, making it a potential therapeutic target for cancer treatment. Understanding the function of SRCIN1 can provide insights into its role in tumorigenesis and drug resistance, offering new possibilities for targeted therapies. Researchers can use this antibody to investigate the mechanisms underlying SRCIN1 activity and explore its potential as a biomarker for cancer diagnosis and prognosis.
Antibody Name:
SRCIN1 Antibody (PACO06718)
Antibody SKU:
PACO06718
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human p140Cap.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 293T HELA cells using p140Cap Polyclonal Antibody.
Western Blot analysis of HeLa cells using p140Cap Polyclonal Antibody.
SNIP: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 17q12Cellular Component: postsynaptic membrane; focal adhesion; axon; cytoplasm; dendrite; postsynaptic density; synapse; actin cytoskeletonMolecular Function: protein binding; protein kinase bindingBiological Process: exocytosis; regulation of cell migration
