The SRCIN1 Polyclonal Antibody (PAC02761) is a valuable tool for researchers studying SRCIN1, a protein involved in cellular processes and signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SRCIN1 protein, this antibody enables the detection and analysis of SRCIN1 in various cell types, making it ideal for studies in molecular biology and cancer research.SRCIN1, also known as a regulator of integrin activity, plays a crucial role in cell adhesion, migration, and invasion processes.
Its involvement in these key cellular functions makes it a promising target for research into cancer metastasis and tumor progression. By elucidating the mechanisms by which SRCIN1 functions, researchers can gain valuable insights into potential therapeutic strategies for combating cancer and other diseases associated with aberrant cell signaling pathways.
Antibody Name:
SRCIN1 Antibody (PACO22761)
Antibody SKU:
PACO22761
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SNIP.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 and HeLa cells, using SNIP antibody.
Background:
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
SNIP: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Interacts with the N-terminal coiled-coil region of SNAP25. Interacts with BCAR1/p130Cas and SRC through its C-terminal domain. Interacts with CSK, CTTN, SORBS3/vinexin, SYP and MAPRE3/EB3. Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. Belongs to the SRCIN1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 17q12Cellular Component: postsynaptic membrane; focal adhesion; axon; cytoplasm; dendrite; postsynaptic density; synapse; actin cytoskeletonMolecular Function: protein binding; protein kinase bindingBiological Process: exocytosis; regulation of cell migration
