The SRPK3 Polyclonal Antibody (PACO03848) is a valuable tool for researchers studying SRPK3, a protein kinase involved in the regulation of alternative splicing. This antibody, developed in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.SRPK3 plays a crucial role in modulating gene expression by regulating the splicing of pre-mRNA, impacting the diversity of protein isoforms generated. Dysregulation of alternative splicing has been implicated in various diseases, including cancer and neurological disorders, making SRPK3 an important target for research.
By using the SRPK3 Polyclonal Antibody, researchers can detect and analyze SRPK3 protein levels in different cell types, providing valuable insights into the role of alternative splicing in various physiological and pathological processes. This antibody is a valuable tool for studies in molecular biology, cancer research, and neurobiology.
Antibody Name:
SRPK3 Antibody
Antibody SKU:
PACO03848
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human SRPK3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
