The ST3GAL6 Antibody (PAC012489) is a polyclonal antibody designed for research involving ST3GAL6, an enzyme involved in the biosynthesis of gangliosides, which play a critical role in cell-cell recognition and cell signaling. The antibody, raised in rabbits, is highly specific and reactive with human samples, making it suitable for use in various research applications such as Western blot and immunohistochemistry.ST3GAL6 is known to be important in the regulation of glycosylation patterns on cell surface proteins, which can impact cellular functions and communication within the body.
Dysregulation of ST3GAL6 has been implicated in various diseases, including cancer and neurological disorders, making it a valuable target for researchers in these fields.By utilizing the ST3GAL6 Antibody, researchers can gain valuable insights into the function and regulation of ST3GAL6 in biological processes, leading to a better understanding of its role in health and disease. This antibody is essential for studies in glycobiology, cancer biology, and neuroscience, providing researchers with a powerful tool for advancing their research.
Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein Potential. Tissue specificity: Ubiquitous.Sequence similarities: Belongs to the glycosyltransferase 29 family.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
