Description
ST5 Antibody (PACO21815)
The ST5 Antibody (PAC021815) is a high-quality polyclonal antibody designed for research involving ST5, a crucial protein involved in various cellular processes. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ST5 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in molecular biology and cancer research.ST5, also known as suppression of tumorigenicity 5, plays a significant role in cell growth regulation and apoptosis, making it a key target for research in cancer biology and therapeutic development.
Understanding the function and regulation of ST5 is essential for elucidating its potential role in tumorigenesis and identifying novel therapeutic strategies for cancer treatment. The ST5 Antibody provides researchers with a valuable tool for investigating the molecular mechanisms underlying ST5-mediated pathways, paving the way for advancements in precision medicine and targeted cancer therapies.
| Antibody Name: | ST5 Antibody (PACO21815) |
| Antibody SKU: | PACO21815 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human ST5. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Lichy J.H., Cell Growth Differ. 3:541-548(1992). |
| Clonality: | Polyclonal |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO205 cells, using ST5 antibody. |
| Synonyms: | Suppression of tumorigenicity 5; HeLa tumor suppression 1; DENN domain-containing protein 2B; ST5; DENND2B |
| UniProt Protein Function: | DENND2B: a guanine nucleotide exchange factor (GEF) that may activate RAB9A and RAB9B. May be involved in cytoskeletal organization and tumorogenicity. Widely expressed with the exception of peripheral blood lymphocytes and lymphoid cell lines. 3 isoforms of the human protein are produced by alternative promoter. Isoform 1 interacts with the SH3 domain of ABL1, is expressed in several epithelial, fibroblast, and tumorigenic cell lines, and seems to be involved in the activation of ERK2. Isoform 3, expressed in primary cells that may be weakly tumorigenic, but not in tumorigenic cell lines, may block ERK2 activation stimulated by ABL1, and may alter cell morphology and cell growth. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Rab Chromosomal Location of Human Ortholog: 11p15 Molecular Function:Rab guanyl-nucleotide exchange factor activity |
| NCBI Summary: | This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78524 |
| NCBI GenInfo Identifier: | 317373507 |
| NCBI Gene ID: | 6764 |
| NCBI Accession: | P78524.3 |
| UniProt Secondary Accession: | P78524,P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6 B2R6X7, B3KXQ6, |
| UniProt Related Accession: | P78524 |
| Molecular Weight: | 70,245 Da |
| NCBI Full Name: | Suppression of tumorigenicity 5 protein |
| NCBI Synonym Full Names: | suppression of tumorigenicity 5 |
| NCBI Official Symbol: | ST5Â Â |
| NCBI Official Synonym Symbols: | HTS1; p126; DENND2BÂ Â |
| NCBI Protein Information: | suppression of tumorigenicity 5 protein; heLa tumor suppression 1; DENN/MADD domain containing 2B |
| UniProt Protein Name: | Suppression of tumorigenicity 5 protein |
| UniProt Synonym Protein Names: | DENN domain-containing protein 2B; HeLa tumor suppression 1 |
| Protein Family: | Suppression of tumorigenicity 5 protein |
| UniProt Gene Name: | ST5Â Â |
| UniProt Entry Name: | ST5_HUMAN |
