The STAG2 Monoclonal Antibody (PACO17042) is a crucial tool for researchers studying the STAG2 protein, a component of the cohesion complex involved in chromosome segregation and DNA repair processes. This antibody, developed using advanced monoclonal technology, offers high specificity and sensitivity for detecting STAG2 in human samples, making it suitable for a range of applications including immunofluorescence and immunohistochemistry.STAG2, a key player in maintaining genomic stability, has been linked to various human cancers, making it a promising target for therapeutic interventions.
By using the STAG2 antibody, researchers can investigate the role of STAG2 in cancer development and progression, providing valuable insights for personalized medicine and targeted therapies. Additionally, studying STAG2 can contribute to our understanding of genetic disorders and potential treatments aimed at restoring DNA integrity.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17042(STAG2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cells, Primary antibody: PACO17042(STAG2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17042(STAG2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms:
stromal antigen 2
UniProt Protein Function:
STAG2: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Transcription, coactivator/corepressor
Biological Process: negative regulation of DNA endoreduplication; protein sumoylation; sister chromatid cohesion
NCBI Summary:
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
