The STAG3 Polyclonal Antibody (PACO02361) is a valuable tool for researchers studying the STAG3 protein, a key player in meiosis and chromosome segregation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting and other applications.STAG3 is essential for proper chromosome pairing and segregation during cell division, making it a crucial protein for maintaining genomic stability. Dysregulation of STAG3 has been linked to various disorders, including infertility and cancer.
By using the STAG3 Polyclonal Antibody, researchers can effectively detect and study the expression and localization of STAG3 in different cell types, providing valuable insights into its function and potential roles in disease pathology.Whether investigating meiotic processes, chromosomal abnormalities, or potential therapeutic targets in cancer, the STAG3 Polyclonal Antibody offers a reliable and accurate tool for conducting in-depth research in molecular biology and genetics.
Antibody Name:
STAG3 Antibody
Antibody SKU:
PACO02361
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human STAG3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
STAG3: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7q22.1Cellular Component: chromosome, pericentric region; extracellular space; nucleus; synaptonemal complexBiological Process: synaptonemal complex assemblyDisease: Premature Ovarian Failure 8
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
