The STARD13 Polyclonal Antibody (PACO05676) is a valuable tool for research involving the STARD13 protein, a key regulator of intracellular membrane trafficking and signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blotting.STARD13, also known as lipid transfer protein RDGB-alpha, is essential for maintaining cellular homeostasis by mediating the transfer of lipids between membranes.
Dysregulation of STARD13 has been implicated in cancer progression and neurodegenerative diseases, making it a promising target for therapeutic interventions. By utilizing this antibody, researchers can study the function and localization of STARD13 in different cell types, shedding light on its role in disease pathogenesis and potential treatment strategies.
Antibody Name:
STARD13 Antibody (PACO05676)
Antibody SKU:
PACO05676
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the N-terminal region of human StARD13.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
STARD13; DLC2; GT650; StAR-related lipid transfer protein 13; 46H23.2; Deleted in liver cancer 2 protein; DLC-2; Rho GTPase-activating protein; START domain-containing protein 13; StARD13
UniProt Protein Function:
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
