The STARD8 Antibody (PAC017163) is a valuable tool for researchers studying STARD8, a protein involved in intracellular lipid transport and metabolism. This polyclonal antibody, produced in rabbits, is highly specific for STARD8 and has been validated for use in various applications, including Western blotting.STARD8, also known as StAR-related lipid transfer domain-containing protein 8, plays a crucial role in regulating the movement of lipids within cells, making it essential for maintaining cellular homeostasis.
Dysregulation of STARD8 has been linked to various diseases, including metabolic disorders and cancer.By using the STARD8 Antibody, researchers can effectively detect and analyze STARD8 protein levels in different cell types, leading to a better understanding of its function in health and disease. This antibody is a valuable tool for studies in lipid metabolism, cancer biology, and metabolic disorders, providing important insights into potential therapeutic targets for these conditions.
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO17163(STARD8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17163(STARD8 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor.
Synonyms:
StAR-related lipid transfer (START) domain containing 8
UniProt Protein Function:
STARD8: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytosol
Molecular Function:GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction
NCBI Summary:
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]
