The STEAP2 Polyclonal Antibody (PAC013629) is a valuable tool for researchers studying STEAP2, a member of the six-transmembrane epithelial antigen of prostate (STEAP) family that plays a role in cell proliferation and tumor growth. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it a reliable choice for Western blot applications. By targeting the STEAP2 protein, researchers can accurately detect and analyze its expression in various cell types, aiding in studies related to cancer biology and tumor progression.
STEAP2 is known to be involved in cellular iron homeostasis and has been implicated in promoting cancer cell survival and metastasis. Its unique functions make it an intriguing target for research on cancer progression and potential therapeutic interventions. By utilizing the STEAP2 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying cancer development and pave the way for the development of targeted therapies for cancer patients.
six transmembrane epithelial antigen of the prostate 2;STEAP2;IPCA1;PCANAP1;PUMPCn;STAMP1;STMP ;
UniProt Protein Function:
STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, integral; Vesicle; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7q21.13Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosolMolecular Function: transporter activity; metal ion binding; cupric reductase activityBiological Process: regulated secretory pathway; Golgi to plasma membrane transport; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
