The STK17A Polyclonal Antibody (PAC019581) is a valuable tool for researchers studying STK17A, a serine/threonine kinase involved in various cellular processes, including cell cycle regulation and apoptosis. This antibody, produced in rabbits, shows high specificity and sensitivity towards human samples, making it suitable for Western blotting applications. By binding to the STK17A protein, this antibody enables detection and analysis in a wide range of cell types, making it an ideal choice for research in areas such as cancer biology and cell signaling pathways.
STK17A, also known as DRAK2 (Death-associated protein kinase-related apoptosis-inducing protein kinase 2), is a key player in the regulation of cell death and survival processes. It has been implicated in the pathogenesis of various diseases, including cancer, making it a promising target for therapeutic interventions. Research into the functions and dysregulation of STK17A can provide valuable insights into the mechanisms underlying disease development and progression, with potential implications for the development of targeted therapies.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19581(STK17A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, 293T cells, Primary antibody: PACO19581(STK17A Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19581(STK17A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.
Synonyms:
serine/threonine kinase 17a
UniProt Protein Function:
DRAK1: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK familyChromosomal Location of Human Ortholog: 7p13Cellular Component: nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: apoptosis; positive regulation of apoptosis; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
