The STK17A Polyclonal Antibody (PAC019582) is a valuable tool for researchers studying the STK17A protein, which plays a role in regulating cell death and survival pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.STK17A, also known as DRAK1, is involved in apoptosis and autophagy processes, making it a key player in cellular homeostasis and survival. Research into STK17A is important for understanding cell signaling pathways and developing therapies for diseases like cancer and neurodegenerative disorders.
By using the STK17A Polyclonal Antibody, researchers can detect and analyze the expression of STK17A in a variety of cell types, providing valuable insights into its function and potential as a therapeutic target. This antibody is a valuable tool for studies in molecular biology, cell signaling, and cancer research.
Antibody Name:
STK17A Antibody (PACO19582)
Antibody SKU:
PACO19582
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human STK17A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19582(STK17A Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19582(STK17A Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.
Synonyms:
serine/threonine kinase 17a
UniProt Protein Function:
DRAK1: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK familyChromosomal Location of Human Ortholog: 7p13Cellular Component: nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: apoptosis; positive regulation of apoptosis; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
