The STK40 Polyclonal Antibody (PACO15679) is specifically designed for researchers studying STK40, a serine/threonine kinase protein involved in various cellular processes. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the STK40 protein, this antibody allows for detection and analysis in different cell types, making it an essential tool for investigations in cell signaling and cancer research.STK40, also known as serine/threonine kinase 40, is a key player in cell cycle regulation and cell proliferation.
Its role in these processes makes it a promising target for research in cancer biology and therapeutic development. By understanding the function of STK40, researchers can uncover new insights into cancer progression and potentially identify novel treatment strategies. Overall, the STK40 Polyclonal Antibody is a valuable tool for researchers looking to delve deeper into the intricate mechanisms of STK40 and its potential implications in cancer biology.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15679(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: PACO15679(STK40 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15679(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
STK40 (Serine/threonine-protein kinase 40), also known as Sugen kinase 495, is a 435 amino acid, protein kinase that may be a negative regulator of NF κ B and p53-mediated gene expression. Localized to both the cytoplasm and the nucleus, STK40 is ubiquitously expressed. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NF κ B-mediated gene transcription.
Synonyms:
serine/threonine kinase 40
UniProt Protein Function:
SHIK: an ubiquitously expressed protein kinase of the CAMK family. Cytoplasmic. May be a negative regulator of NF-kappaB- and p53-mediated gene transcription.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK-Unique familyChromosomal Location of Human Ortholog: 1p34.3Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding
