The STK40 Polyclonal Antibody (PAC015680) is a valuable tool for researchers studying the STK40 protein, which plays a crucial role in cell cycle regulation and cellular proliferation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.STK40 is a serine/threonine kinase that has been implicated in various cellular processes, including cell growth, division, and survival. Dysregulation of STK40 has been associated with cancer development and progression, making it a promising target for cancer research and therapy development.
By specifically binding to the STK40 protein, this antibody allows for the detection and analysis of STK40 expression in different cell types, providing valuable insights into its function and potential as a therapeutic target. Researchers in the fields of oncology and cell biology will find this antibody essential for their studies on STK40 and its role in disease progression.
Antibody Name:
STK40 Antibody (PACO15680)
Antibody SKU:
PACO15680
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human STK40
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15680(STK40 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15680(STK40 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
STK40 (Serine/threonine-protein kinase 40), also known as Sugen kinase 495, is a 435 amino acid, protein kinase that may be a negative regulator of NF κ B and p53-mediated gene expression. Localized to both the cytoplasm and the nucleus, STK40 is ubiquitously expressed. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NF κ B-mediated gene transcription. Similarly, overexpression of STK40 inhibits NF κ B activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.
Synonyms:
serine/threonine kinase 40
UniProt Protein Function:
SHIK: an ubiquitously expressed protein kinase of the CAMK family. Cytoplasmic. May be a negative regulator of NF-kappaB- and p53-mediated gene transcription.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK-Unique familyChromosomal Location of Human Ortholog: 1p34.3Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding
