The STS Polyclonal Antibody (PACO12550) is a powerful tool for researchers studying the STS gene, a key player in hormone metabolism and steroid synthesis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the STS protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in endocrinology and hormone-related diseases.STS, also known as steroid sulfatase, is crucial for converting inactive steroid sulfates into active steroids, playing a vital role in regulating hormone levels in the body.
Dysregulation of the STS gene has been implicated in various conditions, including hormone-dependent cancers, polycystic ovary syndrome, and hormonal imbalances. Understanding the mechanisms of STS activity is essential for developing targeted therapies for these diseases, making the STS Polyclonal Antibody a valuable tool for researchers in the field.
Conversion of sulfated steroid precursors to estrogens during pregnancy.
NCBI Summary:
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
