The STXBP6 Polyclonal Antibody (PACO39706) is specifically designed for researchers studying STXBP6, a protein involved in intracellular membrane trafficking and fusion events. This antibody, developed in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By targeting the STXBP6 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a valuable tool for investigations in cell biology and neurobiology.
STXBP6, also known as Syntaxin Binding Protein 6, is a key player in regulating neurotransmitter release and synaptic vesicle fusion, making it crucial for proper neuronal function. Dysregulation of STXBP6 has been linked to neurological disorders such as epilepsy and schizophrenia, highlighting the importance of studying its molecular mechanisms. By elucidating the role of STXBP6 in cellular processes, researchers can gain insights into understanding and potentially treating these neurological conditions.
Western blot. All lanes: STXBP6 antibody at 2µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24, 12 kDa. Observed band size: 24 kDa.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO39706 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39706 at dilution of 1:100.
Background:
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
Synonyms:
Syntaxin-binding protein 6 (Amisyn), STXBP6
UniProt Protein Function:
STXBP6: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. 3 isoforms of the human protein are produced by alternative splicing.
Biological Process: exocyst localization; Golgi to plasma membrane transport; negative regulation of exocytosis
NCBI Summary:
STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]
