The STYK1 Polyclonal Antibody (PAC020623) is a valuable tool for researchers studying the STYK1 protein, a receptor tyrosine kinase that plays a role in cancer progression and metastasis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By targeting the STYK1 protein, researchers can analyze its expression and function in different cell types, making it an essential component of studies in cancer biology and therapeutic development.
STYK1, also known as NOK, has been implicated in promoting tumor growth, invasion, and resistance to therapy in various cancer types. Its biological functions make it a promising target for investigating novel treatment strategies for cancer patients. Understanding the role of STYK1 in tumor development and progression is essential for the development of targeted therapies that aim to inhibit its activity and improve patient outcomes.
Antibody Name:
STYK1 Antibody (PACO20623)
Antibody SKU:
PACO20623
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human STYK1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: A431 cells, Primary antibody: PACO20623(STYK1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival.
Synonyms:
serine/threonine/tyrosine kinase 1
UniProt Protein Function:
STYK1: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways. Belongs to the protein kinase superfamily. Tyr protein kinase family.Protein type: Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (receptor); Oncoprotein; Membrane protein, integral; Kinase, protein; TK group; TK-Unique familyChromosomal Location of Human Ortholog: 12p13.2Cellular Component: extrinsic to internal side of plasma membrane; plasma membraneMolecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; receptor bindingBiological Process: cell differentiation; cell migration; innate immune response; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
UniProt Protein Details:
NCBI Summary:
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
