The SURF2 Antibody (PAC012589) is a polyclonal antibody designed for research involving SURF2, a protein implicated in protein degradation and cellular regulation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence.SURF2 is a vital component of the endoplasmic reticulum-associated degradation (ERAD) pathway, playing a crucial role in the removal of misfolded proteins from the cell. Dysregulation of SURF2 has been linked to various diseases, including neurodegenerative disorders and cancer.
Studying the function of SURF2 can provide insights into the mechanisms of protein quality control and potential therapeutic targets for these conditions.With its high specificity and sensitivity, the SURF2 Antibody enables accurate detection and analysis of SURF2 expression in different cell types and tissues. This makes it a valuable tool for researchers in the fields of molecular biology, cell biology, and cancer research looking to explore the role of SURF2 in cellular homeostasis and disease pathogenesis.
SURF2: This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene shares a bidirectional promoter with SURF1, which is located on the opposite strand. The function of the encoded protein from this housekeeping gene has not yet been determined. [provided by RefSeq, Jul 2008]Protein type: Unknown functionChromosomal Location of Human Ortholog: 9q34.2Cellular Component: nucleolus; nucleus; plasma membrane
UniProt Protein Details:
NCBI Summary:
This gene shares a bidirectional promoter with surfeit 1 (SURF1; GeneID: 6834), which is located on the opposite strand. It encodes a conserved protein that is expressed in a variety of tissues. [provided by RefSeq, Jul 2013]
