The SYT16 Polyclonal Antibody (PAC022641) is a valuable tool for researchers studying the synaptotagmin 16 (SYT16) protein, which plays a key role in synaptic vesicle exocytosis and neurotransmitter release. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to SYT16, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential reagent for studies in neuroscience and neurobiology.
SYT16 is a member of the synaptotagmin protein family and is involved in calcium-dependent regulation of synaptic vesicle fusion. Dysregulation of SYT16 has been implicated in neurological disorders such as epilepsy and Alzheimer's disease, making it a promising target for therapeutic interventions. Research into the function and regulation of SYT16 is crucial for advancing our understanding of synaptic transmission and developing novel treatments for neurological conditions.
Antibody Name:
SYT16 Antibody (PACO22641)
Antibody SKU:
PACO22641
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SYT16.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from K562 cells, Jurkat cells, 293 cells and HepG2 cells, using SYT16 antibody.
Background:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.
SYT16: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Belongs to the synaptotagmin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 14q23.2Cellular Component: plasma membraneMolecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein binding; syntaxin bindingBiological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion
