The TACC2 Polyclonal Antibody (PAC012619) is a valuable tool for researchers studying TACC2, a protein involved in microtubule organization and cell division. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is suitable for Western blotting applications. By targeting the TACC2 protein, researchers can investigate its role in cellular processes such as mitosis and its potential implications in cancer development.TACC2 is a key player in spindle assembly and chromosome segregation during cell division, making it a crucial molecule to study in the context of cancer biology and therapeutic development.
By elucidating the function of TACC2, researchers can uncover potential targets for anti-cancer treatments and gain insights into the mechanisms underlying tumor growth and metastasis. The TACC2 Polyclonal Antibody offers researchers a reliable tool for investigating the intricate role of TACC2 in cellular physiology and disease progression.
transforming, acid, c coiled-coil containing protein 2;TACC2;AZU-1;ECTACC ;
UniProt Protein Function:
TACC2: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 10q26Cellular Component: microtubule cytoskeleton; nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleusMolecular Function: protein domain specific binding; nuclear hormone receptor bindingBiological Process: cell proliferation; regulation of microtubule-based process; astral microtubule organization and biogenesis; neurogenesis; cerebral cortex development; microtubule cytoskeleton organization and biogenesis; interkinetic nuclear migration
UniProt Protein Details:
NCBI Summary:
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
