The TACC2 Polyclonal Antibody (PAC020648) is a valuable tool for researchers studying TACC2, a protein involved in cell division and microtubule organization. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the TACC2 protein, researchers can accurately detect and study its expression in various cell types.TACC2 plays a crucial role in regulating cell division and ensuring proper chromosome segregation, making it a key target for studies in cancer research and developmental biology.
Understanding the function of TACC2 can provide insight into its involvement in tumor formation and progression, as well as its potential as a therapeutic target. The TACC2 Polyclonal Antibody is an essential tool for researchers aiming to unravel the complexities of cell division and explore the potential applications of targeting TACC2 in disease treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20648(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Mouse muscle tissue, Primary antibody: PACO20648(TACC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20648(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Transforming acid, c coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
transforming, acid, c coiled-coil containing protein 2
UniProt Protein Function:
TACC2: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 10q26Cellular Component: microtubule cytoskeleton; nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleusMolecular Function: protein domain specific binding; nuclear hormone receptor bindingBiological Process: cell proliferation; regulation of microtubule-based process; astral microtubule organization and biogenesis; neurogenesis; cerebral cortex development; microtubule cytoskeleton organization and biogenesis; interkinetic nuclear migration
UniProt Protein Details:
NCBI Summary:
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
