The TACC2 Monoclonal Antibody (PACO20649) is a valuable tool for researchers studying TACC2, a protein involved in cell division and microtubule organization. This antibody, produced through mouse hybridoma technology, is highly specific to TACC2 in human samples and is suitable for use in various applications, including immunofluorescence microscopy and immunoprecipitation.TACC2 is essential for the proper alignment and segregation of chromosomes during cell division, making it a key player in maintaining genomic stability. Dysregulation of TACC2 has been implicated in various diseases, including cancer, where abnormal cell division can lead to tumor formation and progression.
By targeting TACC2 with this monoclonal antibody, researchers can investigate its role in tumorigenesis and potentially identify new therapeutic targets for cancer treatment.Overall, the TACC2 Monoclonal Antibody (PACO20649) is a valuable asset for researchers interested in cell division, microtubule dynamics, and the mechanisms underlying cancer development. Its specificity and reliability make it an essential tool for advancing our understanding of TACC2 function and its implications in disease.
Antibody Name:
TACC2 Antibody (PACO20649)
Antibody SKU:
PACO20649
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TACC2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20649(TACC2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Transforming acid, c coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
transforming, acid, c coiled-coil containing protein 2
UniProt Protein Function:
TACC2: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 10q26Cellular Component: microtubule cytoskeleton; nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleusMolecular Function: protein domain specific binding; nuclear hormone receptor bindingBiological Process: cell proliferation; regulation of microtubule-based process; astral microtubule organization and biogenesis; neurogenesis; cerebral cortex development; microtubule cytoskeleton organization and biogenesis; interkinetic nuclear migration
UniProt Protein Details:
NCBI Summary:
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
