Description
TAF1A Antibody (PACO05664)
The TAF1A Polyclonal Antibody (PACO05664) is a valuable tool for researchers studying TAF1A, a key protein involved in transcriptional regulation. This antibody, produced in rabbits, shows strong reactivity with human samples and has been verified for use in Western blot experiments. By binding to TAF1A, this antibody enables researchers to detect and analyze the protein in a variety of cell types, making it a versatile tool for investigations in molecular biology and gene expression studies.TAF1A, also known as TATA box-binding protein-associated factor 1A, plays a crucial role in the assembly of transcription initiation complexes and regulation of gene expression.
Its involvement in these fundamental cellular processes makes TAF1A a target of interest for research into gene regulation, cellular differentiation, and development. Understanding the function and regulation of TAF1A is essential for unraveling the complex mechanisms governing gene expression and cellular function in various biological systems.
| Antibody Name: | TAF1A Antibody (PACO05664) |
| Antibody SKU: | PACO05664 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human TAF I p48. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TAF1A; TATA box-binding protein-associated factor RNA polymerase I subunit A; RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; |
| UniProt Protein Function: | TAF1A: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q42 Cellular Component: intracellular membrane-bound organelle; microtubule cytoskeleton; nucleoplasm; nucleus; RNA polymerase I transcription factor complex Molecular Function:protein binding Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter |
| NCBI Summary: | This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q15573 |
| NCBI GenInfo Identifier: | 74739864 |
| NCBI Gene ID: | 9015 |
| NCBI Accession: | Q15573.1 |
| UniProt Secondary Accession: | Q15573,Q9NWA1, B2RDZ8, D3DTB7, |
| UniProt Related Accession: | Q15573 |
| Molecular Weight: | 39,615 Da |
| NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor, RNA polymerase I subunit A |
| NCBI Official Symbol: | TAF1AÂ Â |
| NCBI Official Synonym Symbols: | SL1; RAFI48; TAFI48; MGC:17061Â Â |
| NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit A |
| Protein Family: | TATA box-binding protein-associated factor |
| UniProt Gene Name: | TAF1AÂ Â |
| UniProt Entry Name: | TAF1A_HUMAN |
