Description
TAF5L Antibody (PACO01583)
The TAF5L Polyclonal Antibody (PACO01583) is a valuable tool for researchers studying TAF5L, a key protein involved in gene regulation and transcription. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the TAF5L protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an excellent choice for studies in molecular biology and gene expression.TAF5L, part of the TFIID complex, plays a crucial role in facilitating the transcription of genes by RNA polymerase II.
Its involvement in gene regulation makes it a target of interest in understanding various biological processes and diseases. By studying TAF5L, researchers can gain valuable insights into gene expression patterns and potentially identify novel therapeutic targets for conditions such as cancer, developmental disorders, and metabolic diseases. The use of the TAF5L Polyclonal Antibody in research can help advance our understanding of gene regulation and its implications in health and disease.
| Antibody Name: | TAF5L Antibody |
| Antibody SKU: | PACO01583 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human TAF5L. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TAF5L; PAF65B; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; PCAF-associated factor 65 beta; PAF65-beta |
| UniProt Protein Function: | TAF5L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 1q42.13 Molecular Function:histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor activity Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter |
| NCBI Summary: | The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75529 |
| NCBI GenInfo Identifier: | 46577305 |
| NCBI Gene ID: | 27097 |
| NCBI Accession: | O75529.1 |
| UniProt Secondary Accession: | O75529,Q5TDI5, Q5TDI6, Q8IW31, |
| UniProt Related Accession: | O75529 |
| Molecular Weight: | 36,991 Da |
| NCBI Full Name: | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 5 like |
| NCBI Official Symbol: | TAF5LÂ Â |
| NCBI Official Synonym Symbols: | PAF65BÂ Â |
| NCBI Protein Information: | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L |
| UniProt Protein Name: | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L |
| UniProt Synonym Protein Names: | PCAF-associated factor 65 beta; PAF65-beta |
| Protein Family: | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor |
| UniProt Gene Name: | TAF5LÂ Â |
| UniProt Entry Name: | TAF5L_HUMAN |
