The TBC1D22A Polyclonal Antibody (PAC017211) is a vital tool for researchers studying TBC1D22A, a protein involved in cellular processes and signaling pathways. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for use in Western blotting and immunohistochemistry applications. By targeting the TBC1D22A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in cell biology and molecular biology.TBC1D22A is known for its role in regulating cellular functions such as vesicle trafficking, protein transport, and signal transduction.
The protein's involvement in these processes highlights its importance in maintaining cellular homeostasis and functioning. Research on TBC1D22A is crucial for understanding its impact on cell physiology and its potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic conditions. By elucidating the function of TBC1D22A, scientists can uncover new insights into cellular mechanisms and potentially develop novel therapeutic strategies for various health conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17211(TBC1D22A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 cell and human lung cancer tissue, Primary antibody: PACO17211(TBC1D22A Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17211(TBC1D22A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid, protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome.
Synonyms:
TBC1 domain family, member 22A
UniProt Protein Function:
TBC1D22A: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RabChromosomal Location of Human Ortholog: 22q13.3Cellular Component: endomembrane system; intracellularMolecular Function: GTPase activator activity; protein binding; protein homodimerization activity; Rab GTPase bindingBiological Process: intracellular protein transport; regulation of vesicle fusion
